Dworkin M S, Shoemaker P C, Goldoft M J, Kobayashi J M
Centers for Disease Control and Prevention, Epidemiology Program Office, Division of Applied Public Health Training, Epidemic Intelligence Service, Atlanta, GA, USA.
Clin Infect Dis. 2001 Oct 1;33(7):1010-4. doi: 10.1086/322644. Epub 2001 Aug 22.
Reactive arthritis and Reiter's syndrome have been reported following gastroenteritis. Prevalence studies for these conditions are uncommon, and the prevalence of Reiter's syndrome after Salmonella enteritidis infection has not been previously reported. After a large outbreak of S. enteritidis gastroenteritis, a survey of persons exposed to the implicated food source was conducted, and those with reactive arthritis were evaluated for possible risk factors. Among 481 persons responding to the questionnaire, 217 cases of S. enteritidis gastroenteritis were identified (31 confirmed and 186 clinical cases; attack rate, 45%). Twenty-nine percent of the cases had symptoms of reactive arthritis, 3% had symptoms of Reiter's syndrome, and 10% had reactive arthritis with oral ulcers. Markers for severe illness (diarrhea > or =7 days, emergency room visit or hospitalization, and antibiotic treatment) were statistically significant but colinear factors associated with reactive arthritis. Increased awareness of postdysenteric reactive arthritis and Reiter's syndrome is recommended.
据报道，肠胃炎后会出现反应性关节炎和赖特综合征。针对这些病症的患病率研究并不常见，此前也未曾报道过肠炎沙门氏菌感染后赖特综合征的患病率。在一次大规模肠炎沙门氏菌肠胃炎暴发后，对接触相关食物源的人员进行了调查，并对患有反应性关节炎的人员评估了可能的风险因素。在481名回复问卷的人员中，确诊了217例肠炎沙门氏菌肠胃炎病例（31例确诊病例和186例临床病例；发病率为45%）。29%的病例有反应性关节炎症状，3%有赖特综合征症状，10%有伴有口腔溃疡的反应性关节炎。严重疾病的标志物（腹泻≥7天、急诊就诊或住院以及抗生素治疗）具有统计学意义，但与反应性关节炎相关的因素存在共线性。建议提高对痢疾后反应性关节炎和赖特综合征的认识。
