Department of Emergency, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Int J Biol Macromol. 2010 Mar 1;46(2):229-31. doi: 10.1016/j.ijbiomac.2009.12.005. Epub 2009 Dec 16.
A water-soluble oligosaccharide was isolated from the water extract of soybean, which is widely grown worldwide due to its nutritional benefits of a full range of amino acids and a high protein content. In this study, we analysed chemical composition of soybean oligosaccharides (SBOS) using high performance liquid chromatography (HPLC). The results obtained were compared with the following sugar standards: mannose, galactose, xylose, arabinose, fucose and glucose. Results showed that SBOS was composed of galactose (65.3%), mannose (15.6%), fructose (7.8%) and glucose (8.7%). The pharmacological action of SBOS has been studied in hyperlipidemic rats fed high-fat diet. In hyperlipidemic rats, feeding with SBOS (150 and 300 mg/kg b.w.) exerted a pharmacological effect as assessed by reversal of plasma levels of lactic acid, nitric oxide (NO), vascular endothelial growth factor (VEGF) levels, and heart Na+-K+-ATPase, Ca2+-ATPase and Mg2+-ATPase activities. These results indicated that SBOS may have beneficial effects on the therapy of some heart diseases, such as coronary artery diseases.
一种水溶性低聚糖从大豆的水提取物中分离出来，由于其富含各种氨基酸和高蛋白质含量，在全世界范围内广泛种植。在本研究中，我们使用高效液相色谱（HPLC）分析了大豆低聚糖（SBOS）的化学成分。将得到的结果与以下糖标准品进行比较：甘露糖、半乳糖、木糖、阿拉伯糖、岩藻糖和葡萄糖。结果表明，SBOS 由半乳糖（65.3%）、甘露糖（15.6%）、果糖（7.8%）和葡萄糖（8.7%）组成。SBOS 的药理学作用已在高脂饮食喂养的高血脂大鼠中进行了研究。在高血脂大鼠中，用 SBOS（150 和 300mg/kg bw）喂养表现出药理学作用，如血浆乳酸、一氧化氮（NO）、血管内皮生长因子（VEGF）水平以及心脏 Na+-K+-ATP 酶、Ca2+-ATP 酶和 Mg2+-ATP 酶活性的逆转。这些结果表明，SBOS 可能对某些心脏病（如冠状动脉疾病）的治疗具有有益作用。
