Marcy R, Quermonne M A, Nguyen T M
Ann Dermatol Venereol. 1977 Jun-Jul;104(6-7):500-1.
Anhidrotic concentrations 50 of four anticholinergics were determined in mice using an original skin palmar conductance method. Intra-peritoneal, intra-palmar and topical routes were compared. Relative anhidrotic activities according to the mode of administration of the different anticholinergics showed definite differences, e.g. hydroxyzine, which was the less active per i.p. route, was the most active per topical route. The method is likely to be a useful test for selecting the most active anticholinergic and its most efficient route of administration for the treatment of hyperhidrosis.
使用一种原始的手掌皮肤电导法测定了四种抗胆碱能药物在小鼠体内的无汗浓度。比较了腹腔内、手掌内和局部给药途径。根据不同抗胆碱能药物的给药方式，相对无汗活性显示出明显差异，例如，羟嗪经腹腔内途径活性较低，但经局部途径活性最高。该方法可能是一种有用的试验，用于选择治疗多汗症最有效的抗胆碱能药物及其最有效的给药途径。
