Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, United States.
Semin Cell Dev Biol. 2010 Jul;21(5):472-8. doi: 10.1016/j.semcdb.2009.12.008. Epub 2009 Dec 21.
BiP is the mammalian endoplasmic reticulum (ER) Hsp70 orthologue that plays a major role in all functions of this organelle including the seemingly opposing functions of aiding the maturation of unfolded nascent proteins and identifying and targeting chronically unfolded proteins for degradation. The recent identification of mammalian BiP co-factors combined with delineation of the ER degradation machinery and data suggesting that the ER is subdivided into unique regions helps explain how these different functions can occur in the same organelle and raises some unresolved issues.
BiP 是哺乳动物内质网 (ER) 的 Hsp70 直系同源物,在该细胞器的所有功能中发挥主要作用,包括看似相反的功能,即辅助未折叠新生蛋白质的成熟以及鉴定和靶向慢性折叠蛋白质进行降解。最近鉴定了哺乳动物 BiP 共因子,结合 ER 降解机制的描述以及表明 ER 被细分为独特区域的相关数据,有助于解释这些不同的功能如何在同一个细胞器中发生,并提出了一些未解决的问题。