伴侣蛋白介导的自噬在健康和疾病中的作用。
Chaperone-mediated autophagy in health and disease.
机构信息
Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
FEBS Lett. 2010 Apr 2;584(7):1399-404. doi: 10.1016/j.febslet.2009.12.025. Epub 2009 Dec 22.
Abstract
Chaperone-mediated autophagy (CMA) is a lysosomal pathway that participates in the degradation of cytosolic proteins. CMA is activated by starvation and in response to stressors that result in protein damage. The selectivity intrinsic to CMA allows for removal of damaged proteins without disturbing nearby functional ones. CMA works in a coordinated manner with other autophagic pathways, which can compensate for each other. Interest in CMA has recently grown because of the connections established between this autophagic pathway and human pathologies. Here we review the unique properties of CMA compared to other autophagic pathways and its relevance in health and disease.
摘要
伴侣蛋白介导的自噬（CMA）是一种溶酶体途径，参与细胞质蛋白的降解。CMA 由饥饿和应激反应激活，这些反应会导致蛋白质损伤。CMA 的内在选择性允许去除受损的蛋白质，而不会干扰附近的功能蛋白。CMA 与其他自噬途径协调工作，可以相互补偿。由于这种自噬途径与人类病理学之间建立了联系，最近人们对 CMA 的兴趣有所增加。在这里，我们将比较 CMA 与其他自噬途径的独特特性及其在健康和疾病中的相关性。
相似文献
1
Chaperone-mediated autophagy in health and disease.
FEBS Lett. 2010 Apr 2;584(7):1399-404. doi: 10.1016/j.febslet.2009.12.025. Epub 2009 Dec 22.
2
Chaperone-mediated autophagy in aging and disease.
Curr Top Dev Biol. 2006;73:205-35. doi: 10.1016/S0070-2153(05)73007-6.
3
Chaperone-mediated autophagy: selectivity pays off.
Trends Endocrinol Metab. 2010 Mar;21(3):142-50. doi: 10.1016/j.tem.2009.10.003. Epub 2009 Oct 24.
4
Chaperone-mediated autophagy.
Proc Am Thorac Soc. 2010 Feb;7(1):29-39. doi: 10.1513/pats.200909-102JS.
5
Chaperone mediated autophagy in aging: Starve to prosper.
Ageing Res Rev. 2016 Dec;32:13-21. doi: 10.1016/j.arr.2016.07.001. Epub 2016 Jul 30.
6
Chaperone-mediated autophagy: molecular mechanisms and physiological relevance.
Semin Cell Dev Biol. 2010 Sep;21(7):719-26. doi: 10.1016/j.semcdb.2010.02.005. Epub 2010 Feb 20.
7
Methods to study chaperone-mediated autophagy.
Methods. 2015 Mar;75:133-40. doi: 10.1016/j.ymeth.2015.01.003. Epub 2015 Jan 14.
8
Chaperone-mediated autophagy.
Methods Mol Biol. 2008;445:227-44. doi: 10.1007/978-1-59745-157-4_15.
9
Modulating Chaperone-Mediated Autophagy and Its Clinical Applications in Cancer.
Cells. 2022 Aug 17;11(16):2562. doi: 10.3390/cells11162562.
10
Methods to Study Chaperone-Mediated Autophagy.
Methods Enzymol. 2017;588:283-305. doi: 10.1016/bs.mie.2016.10.009. Epub 2016 Nov 18.
引用本文的文献
1
The Role of Chaperone-Mediated Autophagy in Tissue Homeostasis and Disease Pathogenesis.
Biomedicines. 2024 Jan 23;12(2):257. doi: 10.3390/biomedicines12020257.
2
Transcriptomic regulations of heat stress response in the liver of lactating dairy cows.
BMC Genomics. 2023 Jul 20;24(1):410. doi: 10.1186/s12864-023-09484-1.
3
LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles.
Autophagy. 2023 Nov;19(11):2837-2852. doi: 10.1080/15548627.2023.2235196. Epub 2023 Jul 21.
4
A Study on Autophagy Related Biomarkers in Alzheimer's Disease Based on Bioinformatics.
Cell Mol Neurobiol. 2023 Oct;43(7):3693-3703. doi: 10.1007/s10571-023-01379-9. Epub 2023 Jul 7.
5
Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons.
eNeuro. 2023 May 5;10(5). doi: 10.1523/ENEURO.0426-22.2023. Print 2023 May.
6
A selective type of autophagy to maintain glioma stem cell activity.
Stem Cell Investig. 2023 Jan 6;10:1. doi: 10.21037/sci-2022-047. eCollection 2023.
7
Licochalcone B, a Natural Autophagic Agent for Alleviating Oxidative Stress-Induced Cell Death in Neuronal Cells and Models.
Pharmaceuticals (Basel). 2022 Aug 25;15(9):1052. doi: 10.3390/ph15091052.
8
Chaperone-Mediated Autophagy in Pericytes: A Key Target for the Development of New Treatments against Glioblastoma Progression.
Int J Mol Sci. 2022 Aug 10;23(16):8886. doi: 10.3390/ijms23168886.
9
Chaperone-Mediated Autophagy and Its Implications for Neurodegeneration and Cancer.
Int J Gen Med. 2022 Jun 15;15:5635-5649. doi: 10.2147/IJGM.S368364. eCollection 2022.
10
The Role of Chaperone-Mediated Autophagy in Bortezomib Resistant Multiple Myeloma.
Cells. 2021 Dec 8;10(12):3464. doi: 10.3390/cells10123464.
本文引用的文献
1
Chaperone-mediated autophagy: selectivity pays off.
Trends Endocrinol Metab. 2010 Mar;21(3):142-50. doi: 10.1016/j.tem.2009.10.003. Epub 2009 Oct 24.
2
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing.
Hum Mol Genet. 2009 Nov 1;18(21):4153-70. doi: 10.1093/hmg/ddp367. Epub 2009 Aug 4.
3
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.
PLoS One. 2009;4(5):e5515. doi: 10.1371/journal.pone.0005515. Epub 2009 May 13.
4
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.
Science. 2009 Jan 2;323(5910):124-7. doi: 10.1126/science.1166088.
5
Chaperone-mediated autophagy is defective in mucolipidosis type IV.
J Cell Physiol. 2009 May;219(2):344-53. doi: 10.1002/jcp.21676.
6
Autophagy and aging: keeping that old broom working.
Trends Genet. 2008 Dec;24(12):604-12. doi: 10.1016/j.tig.2008.10.002. Epub 2008 Nov 5.
7
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function.
Nat Med. 2008 Sep;14(9):959-65. doi: 10.1038/nm.1851.
8
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane.
Mol Cell Biol. 2008 Sep;28(18):5747-63. doi: 10.1128/MCB.02070-07. Epub 2008 Jul 21.
9
Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.
J Biol Chem. 2008 Aug 29;283(35):23731-8. doi: 10.1074/jbc.M801918200. Epub 2008 Jun 12.
10
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy.
Mol Biol Cell. 2008 May;19(5):2179-92. doi: 10.1091/mbc.e07-11-1155. Epub 2008 Mar 12.
Zotero 插件