Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom.
FEBS Lett. 2010 Feb 19;584(4):719-25. doi: 10.1016/j.febslet.2009.12.023. Epub 2009 Dec 22.
Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1. Analysis of hepcidin mRNA and protein levels in hepatoma cells suggests that its expression may be regulated by divalent metal ions, with zinc inducing maximal effects on hepcidin levels. These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins.
亚铁调素是一种调节铁吸收的小急性相肽。它由炎症和感染诱导，但被贫血和缺氧抑制。在这里，我们进一步揭示铁调素转录还涉及其启动子中的功能金属反应元件（MRE）与 MRE 结合转录因子-1 之间的相互作用。肝癌细胞中铁调素 mRNA 和蛋白水平的分析表明，其表达可能受二价金属离子的调节，其中锌对铁调素水平的诱导作用最大。这些数据表明，这种肽可能是二价金属的多效传感器，其中一些是外源性环境毒素。
