Department of Experimental Medicine, Imperial College London, London W12 0NN, UK.
Rheumatology (Oxford). 2010 Mar;49(3):528-35. doi: 10.1093/rheumatology/kep426. Epub 2009 Dec 21.
To investigate the patterns of myocardial involvement in the presence of self-limiting and sustained systemic inflammation, using MRI.
Ninety-four subjects, with a clinical diagnosis of myocarditis (n = 36), RA (n = 24) and apparently healthy subjects (n = 34, control group), underwent standardized cardiac MRI protocol for the assessment of global and regional morphology and systolic function using balanced steady-state free precession sequences, T2-weighted images and late gadolinium enhancement (LGE) studies.
The three groups were well matched for age, gender and cardiovascular risk factors. The RA group showed markedly increased end-diastolic volumes and reduced ejection fraction (P < 0.05). Antero/inferolateral wall thickness was greater in the myocarditis group and reduced in RA, associated with reduced radial and longitudinal thickening (P < 0.01), and markedly raised T2-oedema ratio and global LGE scores (P < 0.05).
Our results may signify the phenotypic features of myocardial plasticity and deformation in response to self-limiting and sustained inflammatory injury.
利用 MRI 研究存在自限性和持续性全身炎症时心肌受累的模式。
94 名受试者，临床诊断为心肌炎（n=36）、类风湿关节炎（n=24）和健康受试者（n=34，对照组），采用平衡稳态自由进动序列、T2 加权图像和晚期钆增强（LGE）研究进行标准心脏 MRI 协议评估整体和局部形态及收缩功能。
三组在年龄、性别和心血管危险因素方面匹配良好。RA 组舒张末期容积明显增加，射血分数降低（P<0.05）。心肌炎组前/下侧壁厚度增加，RA 组减少，伴有径向和纵向增厚减少（P<0.01），T2 水肿比值和整体 LGE 评分明显升高（P<0.05）。
我们的结果可能表明心肌对自限性和持续性炎症损伤的可塑性和变形的表型特征。
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