Inönü University, Faculty of Medicine, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Malatya, Turkey.
J Clin Gastroenterol. 2010 Jan;44(1):4-8. doi: 10.1097/MCG.0b013e3181b7ead2.
Celiac disease is a common multisystemic disorder that may be diagnosed at any age. Owing to the increasing prevalence, prevention strategies, including encouragement of breastfeeding and introduction of small amounts of gluten whereas still on breastfeeding at fourth to sixth month of age, become more important than before. For avoiding complications of celiac disease, a strict gluten-free diet is essential. A lifelong gluten-free diet may bring about difficulties as avoiding gluten completely is problematic owing to the contamination with gluten of presumably gluten free foods. New therapeutic approaches include enzyme supplementation, correction of the intestinal barrier defect against gluten entry, blocking of gliadin presentation by human leukocyte antigen blockers and tissue transglutaminase inhibitors.
乳糜泻是一种常见的多系统疾病，可在任何年龄诊断。由于患病率的增加，预防策略变得更加重要，包括鼓励母乳喂养和在母乳喂养的第四至第六个月引入少量的麸质。为了避免乳糜泻的并发症，严格的无麸质饮食是必不可少的。由于无麸质食品可能受到麸质污染，因此完全避免麸质会带来问题，因此终生无麸质饮食可能会带来困难。新的治疗方法包括酶补充、纠正对麸质进入的肠道屏障缺陷、阻止人类白细胞抗原阻断剂和组织转谷氨酰胺酶抑制剂对麦胶蛋白的呈现。
