Prescrire Int. 2009 Dec;18(104):279-82.
(1) Most diseases with a strong genetic component and a Mendelian pattern of inheritance are rare or very rare disorders; (2) The most common human diseases result from complex interactions between genetic and environmental factors. They are multifactorial; (3) The simple presence of genes that are associated with a disease is not generally sufficient to determine with certainty that the signs and symptoms that characterise the disease will develop in that individual; (4) The association of a disease with a gene does not mean that the gene causes the disease.
（1）大多数具有强大遗传成分和孟德尔遗传模式的疾病都是罕见或非常罕见的病症；（2）最常见的人类疾病是由遗传和环境因素之间的复杂相互作用导致的。它们是多因素的；（3）与一种疾病相关的基因的简单存在通常不足以确定该个体一定会出现表征该疾病的体征和症状；（4）一种疾病与一个基因的关联并不意味着该基因会导致这种疾病。
