Department of Nuclear Medicine, Edith Wolfson Medical Center, Holon, Israel.
Acta Neurol Scand. 2010 Jun;121(6):370-6. doi: 10.1111/j.1600-0404.2009.01307.x. Epub 2009 Dec 17.
Sildenafil citrate is widely used for erectile dysfunction. The present study examined the short-term effects of sildenafil administration in individuals with cerebrovascular risk factors, including patients with a history of stroke.
Twenty-five consecutive male patients with erectile dysfunction and vascular risk factors were included in the study. A perfusion brain SPECT study was performed at baseline and 1 h after the oral administration of sildenafil.
Associations between any of the risk factors and the perfusion scores were not detected, with the exception of stroke. Stroke patients showed significantly more areas with diminished perfusion after sildenafil administration compared to baseline.
In patients with diabetes or hypertension, a dose of 50 mg sildenafil does not appear to produce detrimental effects on cerebral blood flow. However, patients with a history of stroke may be at increased risk of hemodynamic impairment after the use of sildenafil.
枸橼酸西地那非被广泛用于治疗勃起功能障碍。本研究考察了西地那非给药对有脑血管危险因素个体（包括有卒中病史的患者）的短期影响。
研究纳入了 25 例有勃起功能障碍和血管危险因素的男性患者。在口服西地那非前和 1 小时进行了脑灌注 SPECT 研究。
除了卒中以外，未发现任何危险因素与灌注评分之间存在关联。与基线相比，卒中患者在西地那非给药后显示出明显更多的灌注减少区域。
在糖尿病或高血压患者中，50mg 西地那非的剂量似乎不会对脑血流产生不利影响。然而，有卒中病史的患者在使用西地那非后可能会增加发生血液动力学障碍的风险。
