Achiron Asaf, Hecht Idan, Juza Chen, Barak Adiel, Burgansky-Eliash Zvia
1Department of Ophthalmology, Edith Wolfson Medical Center, 62 Halochamim St, 58100 Holon, Israel.
2Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Eye Vis (Lond). 2018 Dec 5;5:30. doi: 10.1186/s40662-018-0125-y. eCollection 2018.
It has been suggested that Sildenafil may have beneficial therapeutic effects in the treatment of neurodegenerative disorders. The retinal circulation is of significant interest as a marker of cerebral vascular disease since the retinal and cerebral vasculatures share many morphological and physiological properties, yet only the retinal circulation can be directly visualized. Therefore, our aim was to assess the change induced by Sildenafil on retinal blood velocity.
Retinal flow velocity was measured 0.5, 3 and 6 h following administration of 100 mg of Sildenafil using the Retinal Function Imager.
No clinical change in either systemic blood pressure or retinal flow velocities were observed. However, when controlling for heart rate and blood pressure, a significant drop in venous flow velocity 6 h following treatment (mean drop 0.3 ± 0.07; 95% CI: 0.44-0.56, = 0.023) was revealed.
In healthy volunteers, retinal venous flow velocity was significantly reduced at the 6-h time point following Sildenafil treatment. No effect was observed on arterial retinal flow velocity.
有人提出西地那非在治疗神经退行性疾病方面可能具有有益的治疗效果。视网膜循环作为脑血管疾病的一个标志物备受关注，因为视网膜和脑血管系统具有许多形态学和生理学特性，但只有视网膜循环可以直接可视化。因此，我们的目的是评估西地那非对视网膜血流速度的影响。
使用视网膜功能成像仪在给予100毫克西地那非后的0.5、3和6小时测量视网膜血流速度。
未观察到全身血压或视网膜血流速度的临床变化。然而，在控制心率和血压后，发现治疗后6小时静脉血流速度显著下降（平均下降0.3±0.07；95%可信区间：0.44 - 0.56，P = 0.023）。
在健康志愿者中，西地那非治疗后6小时视网膜静脉血流速度显著降低。未观察到对视网膜动脉血流速度的影响。
