Prince Henry's Institute, Monash Medical Centre, Department of Physiology, Monash University, Clayton, Melbourne, Victoria, Australia.
Cancer Res. 2010 Jan 1;70(1):4-7. doi: 10.1158/0008-5472.CAN-09-2257. Epub 2009 Dec 22.
Epidemiological evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase (AMPK) is recognized to be a master regulator of energy homeostasis. One of its actions is to phosphorylate and inhibit the actions of cAMP-responsive element binding protein (CREB)-regulated transcription coactivator 2 (CRTC2). In postmenopausal women, the CREB-dependent regulation of aromatase is a crucial determinant of breast tumor formation through local production of estrogens. We report here that the regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.
流行病学证据支持肥胖与女性乳腺癌之间存在相关性。AMP 激活的蛋白激酶（AMPK）被认为是能量平衡的主要调节因子。其作用之一是磷酸化并抑制 cAMP 反应元件结合蛋白（CREB）调节转录共激活因子 2（CRTC2）的活性。在绝经后妇女中，CREB 依赖性的芳香化酶调节是通过局部产生雌激素来确定乳腺癌形成的关键决定因素。我们在此报告，AMPK 和 CRTC2 对乳腺芳香化酶表达的调节，以响应与肥胖相关的脂肪细胞因子环境的改变，为肥胖与乳腺癌风险之间提供了一个重要联系。
