Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
J Investig Med. 2009 Oct;57(7):789-94. doi: 10.2310/JIM.0b013e3181bb0d49.
The discovery of leptin in 1994 has led to remarkable advances in obesity research. We now know that leptin is a cytokinelike hormone that is produced in adipose tissue and plays a pivotal role in regulation of energy balance and in a variety of additional processes via actions in the central nervous system. This symposium review covers current understandings of neuronal leptin receptor signaling and mechanisms of obesity-related leptin resistance in the central nervous system and provides recent insights into the regulation of peripheral glucose balance by central leptin action in rodents.
1994 年瘦素的发现推动了肥胖研究的重大进展。我们现在知道,瘦素是一种细胞因子样激素,由脂肪组织产生,通过在中枢神经系统中的作用,在调节能量平衡和多种其他过程中发挥关键作用。本次专题讨论会综述了目前对神经元瘦素受体信号转导和中枢神经系统中与肥胖相关的瘦素抵抗机制的理解,并提供了最近关于中枢瘦素作用对啮齿动物外周葡萄糖平衡的调节的新见解。