Hubinont C, Nicolini U, Fisk N M, Tannirandorn Y, Rodeck C H
Institute of Obstetrics and Gynecology, Royal Postgraduate Medical School, London, United Kingdom.
Obstet Gynecol. 1991 Apr;77(4):541-4.
Maternal-fetal glucose gradient and fetal plasma glucose, insulin, and glucagon were measured in 63 fetuses: 34 controls and 29 with growth retardation (nine with and 20 without end-diastolic frequencies in the umbilical artery). Maternal-fetal glucose gradient and fetal glucagon levels were higher in the growth-retarded group than in controls (P less than .001), whereas fetal insulin and glucose concentrations were lower (P less than .001). Although maternal-fetal glucose gradient, fetal glucose, and insulin concentrations were similar among the growth-retarded fetuses, fetuses without end-diastolic frequencies in the umbilical artery had higher fetal glucagon levels (P = .01) than those with end-diastolic frequencies. In growth-retarded fetuses, the increase in fetal glucagon might reflect a compensatory response to hypoglycemia and appears to be a better index of fetal compromise than is glucose or insulin.
对63例胎儿测定母胎血糖梯度以及胎儿血浆葡萄糖、胰岛素和胰高血糖素水平：34例为对照组，29例为生长受限胎儿（其中9例脐动脉舒张末期血流消失，20例脐动脉舒张末期血流未消失）。生长受限组的母胎血糖梯度和胎儿胰高血糖素水平高于对照组（P<0.001），而胎儿胰岛素和葡萄糖浓度较低（P<0.001）。虽然生长受限胎儿的母胎血糖梯度、胎儿葡萄糖和胰岛素浓度相似，但脐动脉舒张末期血流消失的胎儿其胎儿胰高血糖素水平高于有舒张末期血流的胎儿（P=0.01）。在生长受限胎儿中，胎儿胰高血糖素升高可能反映了对低血糖的代偿反应，并且似乎是比葡萄糖或胰岛素更好的胎儿宫内窘迫指标。
