Jones C T, Lafeber H N, Roebuck M M
J Dev Physiol. 1984 Dec;6(6):461-72.
The endocrine changes associated with fetal growth retardation caused by unilateral uterine artery ligation of guinea pigs at day 30 of pregnancy were studied. Plasma hormone levels in fetuses that, about 20 or 30 days later, were 35-50% of normal size were measured by radioimmunoassay. The small fetuses were severely hypoglycaemic and hypoinsulinaemic; both showing close correlation and relationship to the degree of growth retardation. Plasma thyroid and cortisol and concentrations were much lower than normal and that glucagon and androstenedione were much higher. Plasma growth hormone level appeared to be unaffected by growth retardation. The developmental changes in glucagon and thyroid hormone concentrations were consistent with a delay in the timing of prenatal events in growth-retarded fetuses. However the late cortisol rise, although somewhat blunted, still occurred at 58-60 in the small fetal guinea pigs.
研究了妊娠30天时单侧子宫动脉结扎致豚鼠胎儿生长迟缓相关的内分泌变化。通过放射免疫分析法测定了约20或30天后大小为正常大小35%-50%的胎儿的血浆激素水平。小胎儿严重低血糖和低胰岛素血症；两者均与生长迟缓程度密切相关且存在关联。血浆甲状腺素和皮质醇浓度远低于正常水平，而胰高血糖素和雄烯二酮则远高于正常水平。血浆生长激素水平似乎不受生长迟缓影响。胰高血糖素和甲状腺激素浓度的发育变化与生长迟缓胎儿产前事件时间延迟一致。然而，小豚鼠胎儿在58-60天时，皮质醇后期升高虽有所减弱但仍会出现。
