[马钱子碱负载聚乳酸纳米粒的制备及其体外评价]
[Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles].
作者信息
Zhao Jihui, Liu Zhaolin, Xu Jie, Yu Yanyan, Feng Nianping
机构信息
Department of Pharmaceutics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2009 Sep;34(18):2322-4.
OBJECTIVE
To prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs).
METHOD
The Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively.
RESULT
The mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment.
CONCLUSION
The Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro
目的
制备并评价马钱子碱聚乳酸纳米粒（Bru-PLA-NPs）。
方法
采用溶剂扩散法制备Bru-PLA-NPs。分别对所制备的Bru-PLA-NPs的物理、化学性质及体外释放行为进行评价。
结果
所制备的Bru-PLA-NPs平均粒径为95 nm，多分散指数为0.362。ζ电位为-15.68 mV。马钱子碱的平均载药量和包封率分别为7%和37%。体外释放实验结果表明，与马钱子碱溶液相比，Bru-PLA-NPs中马钱子碱呈现明显的缓释行为。
结论
采用溶剂扩散法制备的Bru-PLA-NPs粒径小、载药效率高且体外具有明显的缓释作用
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