el-Mofty S K, Shannon M T, Mustoe T A
Washington University School of Medicine, St. Louis, Mo.
Oral Surg Oral Med Oral Pathol. 1991 Feb;71(2):209-13. doi: 10.1016/0030-4220(91)90471-n.
The majority of primary intraosseous carcinomas of the jaws develop in preexisting odontogenic cysts. These tumors are usually well-differentiated keratinizing carcinomas with relatively good prognosis. Only two of 41 previously reported acceptable cases of primary intraosseous carcinomas from ex-odontogenic cysts were associated with cervical lymph node metastasis. Spindle cell carcinoma is an anaplastic dimorphic neoplasm with poor prognosis. It has a special predilection for the upper aerodigestive tract. This is to our knowledge the first report of spindle cell carcinoma developing in an odontogenic cyst. Cervical lymph node metastasis showing typical histologic features of spindle cell carcinoma was detected 8 months postoperatively. The prognostic implications of this finding are discussed in light of previously reported cases of intraosseous carcinoma arising in odontogenic cysts and of spindle cell carcinoma of the oral cavity.
大多数颌骨原发性骨内癌发生于先前存在的牙源性囊肿。这些肿瘤通常是高分化角化癌，预后相对较好。先前报道的41例源自牙源性囊肿的原发性骨内癌可接受病例中，仅有2例伴有颈部淋巴结转移。梭形细胞癌是一种预后不良的间变性双相肿瘤。它对上呼吸道消化道有特殊的偏好。据我们所知，这是首例在牙源性囊肿中发生的梭形细胞癌报告。术后8个月检测到颈部淋巴结转移，其具有梭形细胞癌的典型组织学特征。根据先前报道的牙源性囊肿中发生的骨内癌及口腔梭形细胞癌病例，对这一发现的预后意义进行了讨论。
