Csáthy L, Pócsi I, Kiss L, Vargáné Oláh A, Balla G
Debreceni Orvostudományi Egyetem, Gyermekklinika.
Orv Hetil. 1991 Mar 3;132(9):451-5.
Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was assayed in 20 polycythemic newborns and prematures, together with 50 prematures suffering from hypoxia on the 1st, 2nd, 4th, 14th, and 28th day after birth. The enzyme was also assayed in 101 healthy newborns which provided normal reference values. NAG activity was factored by the creatinine concentration to given an index. There were significant difference in the NAG indices either between full-term and preterm babies or between appropriate for gestational age (AGA) and small for gestational age (SGA) neonates of the normal group. However, NAG excretion on the first day of life was significantly raised in the case of polycythemic newborns. Following partial plasma exchange, on the 14th day the NAG activity returned to the normal range. NAG activities of premature babies suffering from idiopathic respiratory distress syndrome (IRDS) were significantly elevated on the 1st, 2nd, 4th day but fell sharply to the 14th day. NAG activity fell to normal values by the 28th day. These results suggest that the urinary NAG index is a sensitive indicator of the renal tubular damage during the newborn period.
对20名患有红细胞增多症的新生儿和早产儿以及50名出生后第1天、第2天、第4天、第14天和第28天患有缺氧的早产儿进行了尿N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）活性检测。还对101名健康新生儿进行了该酶的检测，以提供正常参考值。NAG活性通过肌酐浓度进行校正以得出一个指数。在正常组中，足月儿与早产儿之间或适于胎龄（AGA）和小于胎龄（SGA）的新生儿之间，NAG指数存在显著差异。然而，红细胞增多症新生儿出生第一天的NAG排泄量显著升高。在进行部分血浆置换后，第14天NAG活性恢复到正常范围。患有特发性呼吸窘迫综合征（IRDS）的早产儿在第1天、第2天、第4天NAG活性显著升高，但到第14天急剧下降。到第28天NAG活性降至正常水平。这些结果表明，尿NAG指数是新生儿期肾小管损伤的一个敏感指标。
