International Centre for Health and Exercise Research, University of Birmingham, Birmingham, UK.
Psychophysiology. 2010 Mar 1;47(2):323-31. doi: 10.1111/j.1469-8986.2009.00939.x. Epub 2009 Dec 16.
Reduced perception of somatosensory stimulation in patients with essential hypertension may be due to deficits in the ascending somatosensory pathway. Function in the ascending somatosensory pathway was assessed by measuring N9, N13, and N20 somatosensory-evoked potentials in 14 unmedicated essential hypertensives and 22 normotensives. N9 amplitudes were smaller and N13 amplitudes marginally smaller in hypertensives than normotensives. N9 amplitudes were inversely associated with blood pressure. N20 amplitudes and N9, N13, and N20 latencies did not differ between groups. In addition, plexus-to-cord, cord-to-cortex, and plexus-to-cortex conduction times were not different between groups. These data suggest that hypertension affects the peripheral nervous system by reducing the number of active sensory nerve fibers without affecting myelination. However, hypertension does not seem to affect the afferent somatosensory pathway within the brain.
原发性高血压患者的躯体感觉刺激感知降低可能是由于上行躯体感觉通路的缺陷所致。通过测量 14 名未接受药物治疗的原发性高血压患者和 22 名血压正常者的 N9、N13 和 N20 体感诱发电位来评估上行体感通路的功能。与血压正常者相比，高血压患者的 N9 振幅较小，N13 振幅略小。N9 振幅与血压呈负相关。两组间 N20 振幅以及 N9、N13 和 N20 的潜伏期无差异。此外，丛-脊髓、脊髓-皮质和丛-皮质的传导时间在两组之间也无差异。这些数据表明，高血压通过减少活跃感觉神经纤维的数量来影响外周神经系统，而不会影响髓鞘形成。然而，高血压似乎不会影响大脑内的传入躯体感觉通路。
