骨髓增生异常综合征患者外周血 WT1 mRNA 和抗 WT1 抗体水平的预后意义。
Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes.
机构信息
Division of Hematology, Department of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
出版信息
Leuk Res. 2010 Aug;34(8):986-90. doi: 10.1016/j.leukres.2009.11.029. Epub 2010 Jan 19.
Wilms tumor gene (WT1) mRNA expression in peripheral blood cells was examined in 80 patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) transformed from MDS. Serum anti-WT1 antibody titers were also determined in 45 patients. Their long-term follow-up showed that the survival rate became worse as the WT1 mRNA level increased. In particular, a high WT1 mRNA level was a strong predictor of a short time to AML transformation even if adjusted by the International Prognostic Scoring System category. Moreover, high values of anti-WT1 antibody were an independent predictor of longer survival. These data may justify therapeutic strategies targeting WT1 molecules in MDS.
在 80 例从骨髓增生异常综合征（MDS）转化而来的骨髓增生异常综合征（MDS）或急性髓系白血病（AML）患者的外周血细胞中检查了 Wilms 肿瘤基因（WT1）mRNA 表达。还在 45 例患者中测定了血清抗 WT1 抗体滴度。他们的长期随访表明，随着 WT1mRNA 水平的升高，生存率变得更差。特别是，即使通过国际预后评分系统类别进行调整，高 WT1mRNA 水平也是 AML 转化时间短的强烈预测因子。此外，抗 WT1 抗体的高值是生存时间延长的独立预测因子。这些数据可能证明针对 MDS 中 WT1 分子的治疗策略是合理的。
Zotero 插件