Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstrasse 11, Bad Oeynhausen, Germany.
Circ Cardiovasc Interv. 2009 Apr;2(2):85-9. doi: 10.1161/CIRCINTERVENTIONS.108.814046. Epub 2009 Feb 20.
Percutaneous closure of atrial septal defects is well established in children and adults and has been found to improve symptoms and positively influence right-heart remodeling. The aim of this study was to evaluate the efficacy and long-term outcome in adult patients older than 60 years.
The study population comprised 96 patients in the age group of 60 to 84 years. Percutaneous closure was performed effectively in all patients. Functional capacity according to New York Heart Association functional class and peak oxygen uptake (VO(2)max) in the cardiopulmonary exercise testing improved significantly after atrial septal defects closure, especially in patients with a pulmonary-to-systemic flow ratio >2. Echocardiographic measurements of the right ventricular end-diastolic diameter showed a significant decrease. No device-associated complications were observed, but in 16 patients, paroxysmal atrial fibrillation occurred after device implantation.
Percutaneous atrial septal defects closure can be performed safely and with minimal risk even in elderly patients. They profit in terms of symptom reduction, improvement of exercise capacity, and right-heart remodeling.
经皮房间隔缺损封堵术在儿童和成人中已得到广泛应用，已被证实可改善症状并对右心重构产生积极影响。本研究旨在评估 60 岁以上成年患者的疗效和长期结果。
研究人群包括年龄在 60 至 84 岁的 96 例患者。所有患者均成功实施了经皮封堵术。根据纽约心脏协会功能分级和心肺运动试验中的峰值摄氧量（VO₂max），心功能得到显著改善，尤其是在肺-体循环血流比值>2 的患者中。超声心动图测量的右心室舒张末期直径显著减小。未观察到与器械相关的并发症，但在 16 例患者中，器械植入后出现阵发性心房颤动。
即使在老年患者中，经皮房间隔缺损封堵术也可以安全且低风险地进行，他们在减轻症状、改善运动能力和右心重构方面获益。
