Monash Cardiovascular Research Centre, Monash University, Australia.
Circ Cardiovasc Interv. 2009 Dec;2(6):528-34. doi: 10.1161/CIRCINTERVENTIONS.109.892372. Epub 2009 Dec 1.
American College of Cardiology/American Heart Association guidelines recommend >75% of patients with an ST-elevation myocardial infarction receive primary percutaneous coronary interventions (PPCI) within 90 minutes. Despite these recommendations, this goal has been difficult to achieve.
We conducted a prospective interventional study involving 349 patients undergoing PPCI at a single tertiary referral institution to determine the impact of prehospital 12-lead ECG triage and emergency department activation of the infarct team on door-to-balloon time (D2BT). The median D2BT of all patients (n=107) who underwent PPCI after field ECG and emergency department activation of the infarct team (MonashHEART Acute Myocardial Infarction [MonAMI] group) was 56 minutes (interquartile range, 36.5 to 70) compared with the median time of a contemporary group (n=122) undergoing PPCI during the same period but not receiving field triage (non-MonAMI group) of 98 minutes (73 to 126.45). The median D2BT time of 120 consecutive patients who underwent PPCI before initiation of the project (pre-MonAMI group) was 101.5 minutes (72.5 to 134; P<0.001). The proportion of patients who achieved a D2BT of < or = 90 minutes increased from 39% in the pre-MonAMI group and 45% in the non-MonAMI group to 93% in the MonAMI group (P<0.001).
The performance of prehospital 12-lead ECG triage and emergency department activation of the infarct team significantly improves D2BT and results in a greater proportion of patients achieving guideline recommendations.
美国心脏病学会/美国心脏协会指南建议,超过 75%的 ST 段抬高型心肌梗死患者应在 90 分钟内接受直接经皮冠状动脉介入治疗(PPCI)。尽管有这些建议,但这一目标一直难以实现。
我们进行了一项前瞻性介入研究,涉及在一家三级转诊机构接受 PPCI 的 349 例患者,以确定院前 12 导联心电图分诊和急诊科启动梗死团队对门球时间(D2BT)的影响。所有接受院前心电图和急诊科启动梗死团队(MonashHEART 急性心肌梗死 [MonAMI] 组)后行 PPCI 的患者(n=107)的中位 D2BT 为 56 分钟(四分位距,36.5 至 70),而同期未接受院前分诊但行 PPCI 的患者(n=122)的中位 D2BT 为 98 分钟(73 至 126.45)。在项目开始前接受 PPCI 的 120 例连续患者(pre-MonAMI 组)的中位 D2BT 时间为 101.5 分钟(72.5 至 134;P<0.001)。在 pre-MonAMI 组和 non-MonAMI 组中,达到 D2BT<=90 分钟的患者比例分别从 39%和 45%增加到 MonAMI 组的 93%(P<0.001)。
院前 12 导联心电图分诊和急诊科启动梗死团队的表现显著改善了 D2BT,并使更多的患者达到指南推荐。