Singer Adam J, Shembekar Amit, Visram Farid, Schiller Joshua, Russo Valerie, Lawson William, Gomes Carol A, Santora Carolyn, Maliszewski Mary, Wilbert Lisa, Dowdy Eileen, Viccellio Peter, Henry Mark C
Department of Emergency Medicine, Stony Brook University, Stony Brook, NY 11794-8500, USA.
Ann Emerg Med. 2007 Nov;50(5):538-44. doi: 10.1016/j.annemergmed.2007.06.480.
American Heart Association/American College of Cardiology guidelines recommend door-to-balloon times of fewer than 90 minutes in patients with acute ST-segment-elevation myocardial infarction. We hypothesized that immediate activation of an interventional cardiology team (code H) would reduce the time to percutaneous coronary intervention by 1 hour and increase the proportion of patients undergoing percutaneous coronary intervention within 90 minutes of arrival.
Study design was a before-and-after trial in an academic suburban emergency department (ED) with a certified cardiac catheterization laboratory. Subjects were a consecutive sample of patients presenting to the ED with ST-segment-elevation myocardial infarction evident on the initial ECG. Patients without chest pain and refusing catheterization were excluded. The intervention was the use of a central paging system for activation of the interventional cardiology team (attending physician, fellow, nurse, technician) by emergency physicians in patients presenting to the ED with ST-segment-elevation myocardial infarction. Measures were demographic and clinical information collected with standardized data collection forms. Outcomes were door-to-balloon times and the proportion of patients undergoing percutaneous coronary intervention within 90 minutes of arrival. Groups were compared with chi2 and t tests.
There were 97 patients included in the study; 43 were treated in the 2 years before implementation of the code H and 54 patients were treated the subsequent 2 years. Mean age (SD) was 56.9 years (13.7), 27% were women, and 86% were white. Groups were similar in age, sex, and race. Implementation of a code H reduced the median door-to-balloon time by 68 minutes (from 176 to 108 minutes; P<.001) and increased the proportion of patients undergoing percutaneous coronary intervention within 90 minutes from 2.8% to 29.0% (mean difference 26.5; 95% confidence interval 15.0 to 36.9). To determine whether further improvements occurred, 48 patients treated in 2006 showed a 20-minute further reduction in door-to-balloon time; 52% underwent angioplasty within 90 minutes of ED presentation.
Institutional implementation of a protocol that requires emergency physicians to activate an interventional cardiology team response in ED patients with ST-segment-elevation myocardial infarction reduces the door-to-balloon time and increases the proportion of patients undergoing percutaneous coronary intervention within 90 minutes.
美国心脏协会/美国心脏病学会指南建议,急性ST段抬高型心肌梗死患者的门球时间应少于90分钟。我们假设,立即启动介入心脏病学团队(代码H)将使经皮冠状动脉介入治疗时间缩短1小时,并增加患者在到达后90分钟内接受经皮冠状动脉介入治疗的比例。
研究设计为在设有经认证的心脏导管实验室的学术性郊区急诊科进行的前后对照试验。研究对象为连续入选的在初始心电图上显示有ST段抬高型心肌梗死的急诊科患者。排除无胸痛及拒绝行导管插入术的患者。干预措施是使用中央传呼系统,由急诊科的急诊医生为表现为ST段抬高型心肌梗死的患者启动介入心脏病学团队(主治医师、住院医师、护士、技术员)。测量指标为用标准化数据收集表收集的人口统计学和临床信息。观察指标为门球时间以及患者在到达后90分钟内接受经皮冠状动脉介入治疗的比例。采用卡方检验和t检验对组间进行比较。
本研究共纳入97例患者;在实施代码H之前的2年中有43例接受治疗,随后的2年中有54例患者接受治疗。平均年龄(标准差)为56.9岁(13.7),女性占27%,白人占86%。两组在年龄、性别和种族方面相似。实施代码H后,门球时间中位数缩短了68分钟(从176分钟降至108分钟;P<0.001),患者在到达后90分钟内接受经皮冠状动脉介入治疗的比例从2.8%增至29.0%(平均差值26.5;95%置信区间15.0至36.9)。为确定是否有进一步改善,2006年治疗的48例患者的门球时间又进一步缩短了20分钟;52%的患者在急诊科就诊后90分钟内接受了血管成形术。
机构实施一项要求急诊医生为急诊科ST段抬高型心肌梗死患者启动介入心脏病学团队响应的方案,可缩短门球时间,并增加患者在到达后90分钟内接受经皮冠状动脉介入治疗的比例。