Peiris Vasum, Singh Tajinder P, Tworetzky Wayne, Chong Erin C, Gauvreau Kimberlee, Brown David W
Department of Cardiology, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Circ Cardiovasc Qual Outcomes. 2009 Jul;2(4):354-60. doi: 10.1161/CIRCOUTCOMES.108.802868. Epub 2009 Jun 9.
Access to beneficial novel healthcare technology has been inequitable in the United States. Fetal echocardiography, used with increasing frequency for prenatal diagnosis (PD) of congenital heart disease, allows for optimal neonatal management and possible improved outcomes. We sought to evaluate whether PD of critical congenital heart disease is related to socioeconomic (SE) position, medical insurance, and race.
In a retrospective review of infants with critical congenital heart disease who underwent surgical or catheter intervention at age <30 days in our institution during 2003 to 2006, we extracted 6 SE variables for the block groups of patient residence from 2000 US Census and calculated a previously validated composite SE score for each patient. PD occurred in 222 (50%) infants. Race was not significantly associated with PD. Private insurance patients were much more likely to have PD (odds ratio, 3.7 versus public insurance; 95% CI, 2.4 to 5.7; P<0.001), as were patients of higher SE position (PD, 62% in highest quartile versus 35% in lowest quartile; P=0.001). Odds of PD increased with increasing SE score (odds ratio, 1.7, 2.3, and 2.9 for each quartile of higher SE score versus those in lowest SE quartile; P<0.001). Patients from economically poor neighborhoods were less likely to have PD (odds ratio, 1.2 for each 10% increase in prevalence of poverty; P=0.04). Private medical insurance (odds ratio, 3.4; 95% CI, 2.1 to 5.5; P<0.001) was the strongest predictor of PD in the logistic regression model.
Patients with public insurance and lower SE position are less likely to have a PD of critical congenital heart disease.
在美国,获取有益的新型医疗技术存在不公平现象。胎儿超声心动图在先天性心脏病产前诊断(PD)中的使用频率不断增加,有助于实现最佳的新生儿管理并可能改善预后。我们旨在评估严重先天性心脏病的产前诊断是否与社会经济(SE)地位、医疗保险和种族有关。
在对2003年至2006年期间在我们机构接受手术或导管介入治疗的年龄小于30天的严重先天性心脏病婴儿进行的回顾性研究中,我们从2000年美国人口普查中提取了患者居住街区组的6个社会经济变量,并为每位患者计算了先前验证过的综合社会经济得分。222名(50%)婴儿接受了产前诊断。种族与产前诊断无显著关联。与公共保险患者相比,私人保险患者更有可能接受产前诊断(优势比为3.7,而公共保险为2.4至5.7;95%可信区间;P<0.001),社会经济地位较高的患者也是如此(产前诊断,最高四分位数组为62%,最低四分位数组为35%;P=0.001)。产前诊断的几率随着社会经济得分的增加而增加(与最低社会经济四分位数组相比,较高社会经济得分的每个四分位数的优势比分别为1.7、2.3和2.9;P<0.001)。来自经济贫困社区的患者接受产前诊断的可能性较小(贫困患病率每增加10%,优势比为1.2;P=0.04)。在逻辑回归模型中,私人医疗保险(优势比为3.4;95%可信区间为2.1至5.5;P<0.001)是产前诊断的最强预测因素。
参加公共保险且社会经济地位较低的患者接受严重先天性心脏病产前诊断的可能性较小。