Dipartimento di Scienze Farmacologiche, Policlinico Via del Vespro, Palermo, Italy.
Anticancer Res. 2009 Nov;29(11):4417-22.
Pure signet-ring cell colorectal carcinoma (SRCC) is an infrequent and highly malignant histological variant of colorectal cancer (CRC), while it is present as a histological component in colorectal carcinomas more frequently.
The aim of this work was to widen the knowledge of the biological factors involved in the pathogenesis and aggressiveness of SRCC by the identification and evaluation of possible molecular abnormalities. By means of immunohistochemistry the expression of the proteolytic degradation enzyme matrix metalloprotease (MMP)-1, that is a collagenase specifically degrading collagens I, II, III and of the adhesion proteins E-cadherin, beta-catenin and fibronectin which are usually involved in the carcinogenesis of conventional colorectal tumours was investigated.
SRCCs showed a significantly greater MMP-1 expression compared to the ordinary intestinal colorectal cancer (ICRC) and a significantly reduced E-cadherin, beta-catenin and fibronectin expression.
The biological aggressiveness and strong metastatic behaviour of SRCC could be due to high MMP-1 and low expression of the adhesion molecules.
纯印戒细胞结直肠癌（SRCC）是一种罕见且高度恶性的结直肠癌（CRC）组织学变体，而在结直肠癌中更常出现作为组织学成分。
本研究的目的是通过鉴定和评估可能的分子异常，拓宽对 SRCC 发病机制和侵袭性相关生物学因素的认识。通过免疫组织化学方法，研究了蛋白水解降解酶基质金属蛋白酶（MMP）-1的表达，该酶特异性降解 I、II、III 型胶原，以及黏附蛋白 E-钙黏附素、β-连环蛋白和纤维连接蛋白的表达，这些蛋白通常参与常规结直肠肿瘤的发生。
SRCC 与普通肠结直肠癌（ICRC）相比，MMP-1 表达显著增加，而 E-钙黏附素、β-连环蛋白和纤维连接蛋白表达显著降低。
SRCC 的生物学侵袭性和强烈的转移行为可能是由于 MMP-1 高表达和黏附分子低表达所致。
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