Kanagawa University of Human Services,Yokosuka, Kanagawa, 238-8522 Japan.
Anticancer Res. 2009 Nov;29(11):4751-8.
Stromal cell-derived factor (SDF)-1 and CXCR4 form an important chemokine ligand/receptor pair. Recent studies suggest that CXCR4 is expressed in certain cancer cells, and malignant cells use this chemokine/receptor system to promote tumor progression and metastasis. However, the pathophysiological significance of their expression in gastric cancer tissue has not been fully elucidated.
SDF-1 and CXCR4 expression levels in gastric cancer specimens obtained from 124 patients were examined by immunohistochemistry.
The staining intensity of CXCR4 and SDF-1 in cancer cells was significantly higher in intestinal-type than in diffuse-type gastric cancer. There was a significant correlation between the expression of CXCR4 and SDF-1 and liver metastasis and lymphatic metastasis in the intestinal-type cancer; however, this correlation was not found in the diffuse-type cancer. Furthermore, intestinal-type cancer cells that permeated the vascular or lymphatic channels as well as liver and lymph node metastases showed strong CXCR4 and SDF-1 staining.
The overexpressed CXCR4 and SDF-1 in intestinal-type cancer cells may be therapeutic targets for preventing lymphatic and hematogenous metastasis.
基质细胞衍生因子 (SDF)-1 和 CXCR4 形成了一个重要的趋化因子配体/受体对。最近的研究表明，CXCR4 在某些癌细胞中表达，恶性细胞利用这种趋化因子/受体系统来促进肿瘤的进展和转移。然而，它们在胃癌组织中的表达的病理生理意义尚未完全阐明。
通过免疫组织化学检查了 124 名患者的胃癌标本中 SDF-1 和 CXCR4 的表达水平。
在肠型胃癌中，癌细胞中 CXCR4 和 SDF-1 的染色强度明显高于弥漫型胃癌。在肠型癌症中，CXCR4 和 SDF-1 的表达与肝转移和淋巴转移之间存在显著相关性；然而，在弥漫型癌症中没有发现这种相关性。此外，浸润血管和淋巴管以及肝和淋巴结转移的肠型癌细胞显示出强烈的 CXCR4 和 SDF-1 染色。
肠型癌细胞中过表达的 CXCR4 和 SDF-1 可能是预防淋巴和血行转移的治疗靶点。
