Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Japan.
J Atheroscler Thromb. 2009;16(6):764-71. doi: 10.5551/jat.2428. Epub 2009 Dec 22.
Loss or gain in obesity indexes, such as body mass index (BMI) and waist circumference (WC), may affect serum lipid parameters. We therefore analyzed the impact of changes in WC and BMI over a one-year period on serum levels of LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides (TG).
We analyzed the data of 3,111 individuals who were not on lipid- lowering medication and who underwent general health screening two years running.
The correlation between percent changes of WC (%dWC) and BMI (%dBMI) were both statistically significantly correlated with percent changes in LDL-C (%dLDL), HDL-C (%dHDL), and TG (%dTG) except that between %dWC and %dHDL in women. In multiple regression analysis, %dBMI, but not %dWC, was found to be an independent predictor of %dLDL, %dHDL, and %dTG. When %dBMI was excluded from the variables, %dWC was identified as an independent factor predicting %dLDL and %dTG; however, in individuals with %dBMI of > or =0, %dWC was not found to be a predictor of percent changes in any lipid parameters tested in this model.
Percent changes in BMI were found to be an independent predictor of adverse changes in lipid parameters in both genders. Although percent changes in WC (%dWC) also tended to confer adverse changes in lipid parameters, this relationship did not remain statistically significant after controlling for %dBMI. It is suggested that changes in obesity parameters are an important goal to avoid adverse lipid changes, although there might be some gender differences.
肥胖指数（如体重指数 BMI 和腰围 WC）的增减可能会影响血清脂质参数。因此，我们分析了一年内 WC 和 BMI 的变化对 LDL 胆固醇（LDL-C）、HDL 胆固醇（HDL-C）和甘油三酯（TG）血清水平的影响。
我们分析了两年内接受过一般健康筛查且未服用降脂药物的 3111 名个体的数据。
WC（%dWC）和 BMI（%dBMI）的百分比变化与 LDL-C（%dLDL）、HDL-C（%dHDL）和 TG（%dTG）的百分比变化均呈统计学显著相关，除女性的%dWC 和%dHDL 之间外。多元回归分析显示，%dBMI 而不是 %dWC 是%dLDL、%dHDL 和%dTG 的独立预测因子。当将%dBMI 从变量中排除时，%dWC 被确定为预测%dLDL 和%dTG 的独立因素；然而，在%dBMI≥0 的个体中，%dWC 并不是本模型中测试的任何脂质参数百分比变化的预测因子。
BMI 的百分比变化被发现是两性中脂质参数不良变化的独立预测因子。尽管 WC 的百分比变化（%dWC）也倾向于导致脂质参数的不良变化，但在控制%dBMI 后，这种关系不再具有统计学意义。建议改变肥胖参数是避免不良脂质变化的一个重要目标，尽管可能存在一些性别差异。
