Department of Pathology, Medical College of Wisconsin, Milwaukee, 53226, USA.
Adv Anat Pathol. 2010 Jan;17(1):12-22. doi: 10.1097/PAP.0b013e3181c6a524.
Histiocytic proliferations involving the lung span a broad spectrum. Some proliferations are primary; others represent a histiocytic response secondary to conditions in which there may be isolated lung involvement or the lung may be involved as part of a systemic process. Primary histiocytic lung disorders, particularly those of uncertain histogenesis are a heterogeneous and intriguing group of disorders. Although they have been the focus of attention by clinicians and pathologists alike, much is unknown about their etiopathogenesis. Owing to this uncertainty, our understanding of these processes is in a state of flux, and is likely to change as more information is brought to light. This review will focus on pulmonary histiocytic proliferations of uncertain histogenesis. Other histiocytic lesions will be dealt with in brief.
涉及肺部的组织细胞增生具有广泛的谱。一些增生是原发性的；其他则代表组织细胞反应，继发于可能存在孤立性肺部受累或肺部受累作为全身性过程一部分的情况。原发性组织细胞性肺部疾病，特别是那些组织发生不确定的疾病，是一组异质性且引人关注的疾病。尽管它们一直是临床医生和病理学家关注的焦点，但对于它们的病因发病机制知之甚少。由于这种不确定性，我们对这些过程的理解处于不断变化的状态，并且随着更多信息的揭示，这种理解可能会发生变化。本综述将重点关注组织发生不确定的肺组织细胞增生。其他组织细胞病变将简要介绍。
