新型 2-(E)-氰基(噻唑烷-2-亚基)噻唑的区域选择性合成。
Regioselective synthesis of new 2-(E)-cyano(thiazolidin-2-ylidene)thiazoles.
机构信息
Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, 91775-1436 Mashhad, Iran.
出版信息
Molecules. 2009 Nov 25;14(12):4849-57. doi: 10.3390/molecules14114849.
Cyclocondensation of 2-[bis(methylthio)methylene]malononitrile (1) and cysteamine (2) afforded 2-(thiazolidin-2-ylidene)malononitrile (3). This compound on treatment with NaSH gave the corresponding thioamide derivative 4a in a regioselective manner on the basis of its single crystal X-ray diffraction analysis. Reaction of this compound with several alpha-bromocarbonyl compounds gave new 2-(E)-cyano(thiazolidin-2-ylidene)thiazoles 5a-g.
2-[双(甲硫基)亚甲基]丙二腈（1）与半胱胺（2）环缩合得到 2-（噻唑烷-2-亚基）丙二腈（3）。根据其单晶 X 射线衍射分析，该化合物与 NaSH 反应以区域选择性方式得到相应的硫代酰胺衍生物 4a。该化合物与几种α-溴羰基化合物反应得到新的 2-（E）-氰基（噻唑烷-2-亚基）噻唑 5a-g。
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