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基于菲的生物碱的合成及抗肿瘤活性。

Synthesis and antitumor activities of phenanthrene-based alkaloids.

机构信息

Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China.

出版信息

Molecules. 2009 Dec 7;14(12):5042-53. doi: 10.3390/molecules14125042.

DOI:10.3390/molecules14125042
PMID:20032876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6255436/
Abstract

A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC(50) values of 11.6 and 6.1 microM, respectively.

摘要

一系列基于菲的千里光碱衍生物（PBTs）被合成，并评估了它们对 H460 人非小细胞肺癌细胞系的细胞毒性活性。在这些化合物中，N-(3-羟基-2,6,7-三甲氧基菲-9-基甲基）-L-脯氨酸（5a）和 N-(3-羟基-2,6,7-三甲氧基菲-9-基甲基）-L-缬氨酸（9）表现出良好的活性，IC50 值分别为 11.6 和 6.1 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3de/6255436/520832bd7efb/molecules-14-05042-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3de/6255436/520832bd7efb/molecules-14-05042-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3de/6255436/520832bd7efb/molecules-14-05042-sch001.jpg

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