1-芳基磺酰基-2-(吡啶甲基亚磺酰基)苯并咪唑类化合物作为新型质子泵抑制剂前药。
1-Arylsulfonyl-2-(pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs.
机构信息
Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
出版信息
Molecules. 2009 Dec 15;14(12):5247-80. doi: 10.3390/molecules14125247.
Abstract
New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
摘要
新型芳基砜基质子泵抑制剂（PPI）前药形式被合成。这些前药提供了更久的有效 PPI 血浆浓度的停留时间，从而更好地抑制胃酸。
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