Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Mlynskádolina CH-2, 842 15 Bratislava, Slovakia.
Molecules. 2009 Dec 23;14(12):5382-8. doi: 10.3390/molecules14125382.
Eleven new 2-styrylbenzothiazole-N-oxides have been prepared by aldol - type condensation reactions between 2-methylbenzothiazole-N-oxide and para-substituted benzaldehydes. Compounds with cyclic amino substituents showed typical push-pull molecule properties. Four compounds were tested against various bacterial strains as well as the protozoan Euglena gracilis as model microorganisms. Unlike previously prepared analogous benzothiazolium salts, only weak activity was recorded.
已经通过 2-甲基苯并噻唑-N-氧化物与取代的苯甲醛之间的醛醇缩合反应制备了 11 种新的 2-取代基苯并噻唑-N-氧化物。具有环状氨基取代基的化合物表现出典型的推拉分子特性。四种化合物针对各种细菌菌株以及原生动物眼虫进行了测试，作为模型微生物。与以前制备的类似苯并噻唑翁盐不同，仅记录到弱活性。
