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银屑病患者循环中 Th17、Th22 和 Th1 细胞增加。

Circulating Th17, Th22, and Th1 cells are increased in psoriasis.

机构信息

Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA.

出版信息

J Invest Dermatol. 2010 May;130(5):1373-83. doi: 10.1038/jid.2009.399. Epub 2009 Dec 24.

DOI:10.1038/jid.2009.399
PMID:20032993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2892169/
Abstract

Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear. Using 7-color flow cytometry, circulating Th17, Th22, and Th1 cells were quantified in 21 untreated psoriatics and 17 healthy individuals. CCR6 was the best cell surface marker for IL-17A+ cells when compared with IL-23R or CD161. CCR6+, IL-17A+, IL-22+, CCR6+IL-17A+, CCR6+IL-22+, CCR6+tumor necrosis factor-alpha+, IL-17A+IFN-gamma-, IL-17A+IL-22+IFN-gamma-, and IL-17A+IL-22-IFN-gamma- cells were increased in psoriatics (all values P<0.001), indicating elevations in circulating Th17 cells, using multiple criteria to define these cells. Th22 (IL-17A-IL-22+IFN-gamma-, P<0.05) and Th1 (IL-17A-IFN-gamma+, P<0.05) cells were also increased in psoriatics, but to a lesser extent. Inhibition of either NF-kappaB or STAT3 in vitro blocked cytokine production by both Th17 and Th1 cells. Circulating levels of Th17 and Th1 cells decreased in a subset of five psoriasis patients serially evaluated following induction therapy with infliximab. In summary, elevated numbers of circulating inflammatory T cells may contribute to cutaneous inflammation and systemic inflammatory disease that occurs in individuals with psoriasis.

摘要

Th17、Th22 和 Th1 细胞在银屑病皮损中被检测到，并与银屑病发病机制有关，但血液中炎症性 T 细胞的数量以及每种细胞类型的相对重要性尚不清楚。本研究使用 7 色流式细胞术，在 21 例未经治疗的银屑病患者和 17 例健康个体中定量检测了循环 Th17、Th22 和 Th1 细胞。与 IL-23R 或 CD161 相比，CCR6 是 IL-17A+细胞的最佳细胞表面标志物。CCR6+、IL-17A+、IL-22+、CCR6+IL-17A+、CCR6+IL-22+、CCR6+肿瘤坏死因子-α+、IL-17A+IFN-γ-、IL-17A+IL-22+IFN-γ-和 IL-17A+IL-22-IFN-γ-细胞在银屑病患者中增加（所有值 P<0.001），表明使用多种标准定义这些细胞时，循环 Th17 细胞升高。Th22（IL-17A-IL-22+IFN-γ-，P<0.05）和 Th1（IL-17A-IFN-γ+，P<0.05）细胞也在银屑病患者中增加，但程度较轻。体外抑制 NF-κB 或 STAT3 可阻断 Th17 和 Th1 细胞的细胞因子产生。在接受英夫利昔单抗诱导治疗的五例银屑病患者的亚组中，循环 Th17 和 Th1 细胞的水平下降。综上所述，循环炎症性 T 细胞数量的增加可能导致银屑病患者发生皮肤炎症和全身炎症性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/9452f5a5bf9b/nihms210591f6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/9c2b1601689c/nihms210591f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/88f6acc1f729/nihms210591f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/9452f5a5bf9b/nihms210591f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/bd55cf2bd98a/nihms210591f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/18c432515f9b/nihms210591f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/fd533fadb39e/nihms210591f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/9c2b1601689c/nihms210591f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/88f6acc1f729/nihms210591f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c42/2892169/9452f5a5bf9b/nihms210591f6.jpg

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Interleukin-17 and type 17 helper T cells.白细胞介素-17与17型辅助性T细胞
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Memory IL-22-producing CD4+ T cells specific for Candida albicans are present in humans.人类体内存在对白色念珠菌具有特异性的产生白细胞介素-22的记忆性CD4 + T细胞。
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Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis.Th17细胞因子在体外和体内均可刺激角质形成细胞中CCL20的表达：对银屑病发病机制的影响。
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