Wang Xi, Jia Yan, He Huaming
Beijing Key Laboratory of Plant Resources Research and Development, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
Institute of Cosmetic Regulatory Science, Beijing Technology and Business University, Beijing 100048, China.
Int J Mol Sci. 2024 Dec 30;26(1):246. doi: 10.3390/ijms26010246.
Lipids are intimately associated with skin condition. This review aims to discuss the function of linoleic acid (LA, 18:2, ω-6), an essential fatty acid, in skin health and hair growth. In skin, LA can be metabolized into ω-6 unsaturated fatty acid, oxidized derivatives and incorporated into complex lipid molecules, including ω-hydroxy-ceramides. Previous research has revealed that skin diseases including acne, atopic dermatitis and psoriasis are associated with disordered LA metabolism. Studies based on animal or skin cell models suggest that LA or LA-rich vegetable oils, topically applied, exhibit diverse biological activities, including the repair of the skin barrier, the promotion of wound healing, skin whitening, photoprotection, anti-inflammatory effects and the stimulation of hair growth. Moreover, the underlying mechanisms of LA's beneficial effects on skin are summarized. Further research on the correlation of LA metabolism and skin disorders, a deeper exploration of the mechanisms underlying the function of LA in skin management and more investigations of its clinical application are required to enhance the understanding and utilization of LA in cosmetics and pharmaceuticals.
脂质与皮肤状况密切相关。本综述旨在探讨必需脂肪酸亚油酸（LA，18:2，ω-6）在皮肤健康和头发生长中的作用。在皮肤中，亚油酸可代谢为ω-6不饱和脂肪酸、氧化衍生物，并并入复杂的脂质分子，包括ω-羟基神经酰胺。先前的研究表明，痤疮、特应性皮炎和银屑病等皮肤病与亚油酸代谢紊乱有关。基于动物或皮肤细胞模型的研究表明，局部应用亚油酸或富含亚油酸的植物油具有多种生物活性，包括修复皮肤屏障、促进伤口愈合、皮肤美白、光保护、抗炎作用以及刺激头发生长。此外，还总结了亚油酸对皮肤有益作用的潜在机制。为了加强对亚油酸在化妆品和制药领域的理解和利用，需要进一步研究亚油酸代谢与皮肤疾病的相关性，更深入地探索亚油酸在皮肤管理中作用的潜在机制，并对其临床应用进行更多研究。
