Department of Kinesiology, University of Massachusetts, 106 Totman Building, Amherst, MA 01003, USA.
Eur J Appl Physiol. 2010 Apr;108(6):1181-7. doi: 10.1007/s00421-009-1325-x. Epub 2009 Dec 23.
The purpose of this study was to compare fasting and post-prandial glucose concentrations measured in venous blood with continuous glucose monitoring (CGM)-derived values, with and without prior exercise, in insulin-resistant, normoglycemic women. Interstitial and venous glucose concentrations were assessed in ten sedentary, overweight/obese African-American women following a sedentary condition (75 min of rest) and following an exercise condition (75 min of brisk walking on a treadmill). Ninety minutes after rest or exercise, participants completed an oral glucose tolerance test (OGTT). In response to the OGTT, CGM-derived glucose area under the curves (AUC) were lower than venous values in the exercise condition (-25%, p = 0.03) but this difference was attenuated in the sedentary condition (-10%, p = 0.09). Additionally, CGM-derived absolute glucose values (mMol) were significantly lower compared to venous values during the sedentary (p = 0.007) and exercise conditions (p = 0.006). Overall, there was a moderately strong relationship between venous and CGM-derived glucose AUC (r (2) = 0.68) but the CGM-derived values were consistently lower in this study group. Although CGM provided more information regarding post-prandial glucose responses, these results suggest that CGM may not closely match venous glucose measurements in normoglycemic participants.
本研究旨在比较静脉血空腹和餐后血糖浓度与连续血糖监测（CGM）衍生值，无论是否有预先运动，在胰岛素抵抗、血糖正常的女性中。在休息 75 分钟的安静状态和在跑步机上快速行走 75 分钟的运动状态后，评估了十名久坐、超重/肥胖的非裔美国女性的间质和静脉血糖浓度。休息或运动 90 分钟后，参与者完成口服葡萄糖耐量试验（OGTT）。OGTT 后，CGM 衍生的葡萄糖曲线下面积（AUC）在运动条件下低于静脉值（-25%，p=0.03），但在安静条件下这种差异减弱（-10%，p=0.09）。此外，与静脉值相比，CGM 衍生的绝对葡萄糖值（mmol）在安静（p=0.007）和运动条件下（p=0.006）均显著降低。总的来说，静脉和 CGM 衍生的葡萄糖 AUC 之间存在中度强关系（r (2) = 0.68），但在本研究组中，CGM 衍生值始终较低。尽管 CGM 提供了更多关于餐后血糖反应的信息，但这些结果表明 CGM 可能与血糖正常参与者的静脉血糖测量值不一致。
