小鼠基因组的化学诱变与精细结构功能分析

Chemical mutagenesis and fine-structure functional analysis of the mouse genome.

作者信息

Rinchik E M

机构信息

Biology Division, Oak Ridge National Laboratory, TN 37831-8077.

出版信息

Trends Genet. 1991 Jan;7(1):15-21. doi: 10.1016/0168-9525(91)90016-j.

DOI:10.1016/0168-9525(91)90016-j

PMID:2003334

Abstract

Heritable mutations constitute important raw materials for mammalian developmental genetics and general genome studies. Mutations induced by high-efficiency chemical mutagenesis of germ cells in mice can be used in genetic and molecular studies to complement physical-mapping strategies and to examine the nature and extent of the functional complexities hidden within the mammalian genome.

摘要

可遗传突变是哺乳动物发育遗传学和一般基因组研究的重要原材料。通过对小鼠生殖细胞进行高效化学诱变诱导产生的突变，可用于遗传和分子研究，以补充物理图谱绘制策略，并探究隐藏在哺乳动物基因组中的功能复杂性的本质和程度。