利用近交系小鼠品系在自然杀伤细胞基因位点中定位巨细胞病毒感染细胞的识别受体。
Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus.
作者信息
Fodil-Cornu Nassima, Pyzik Michal, Vidal Silvia M
机构信息
Department of Human Genetics, McGill University, Montreal, QC, Canada.
出版信息
Methods Mol Biol. 2010;612:393-409. doi: 10.1007/978-1-60761-362-6_27.
Genetically distinct inbred strains of mice that differ in their susceptibility to mouse cytomegalovirus (MCMV) are invaluable for dissecting complex host-pathogen interactions. Their study has allowed the identification of host-resistance loci, including several activating NK cell receptors of major histocompatibility complex (MHC) class I. In this chapter, we provide a practical guide to the genetic mapping and functional characterization of NK cell receptors that control innate immunity against MCMV via specific recognition of infected cells.
对小鼠巨细胞病毒（MCMV）易感性不同的基因不同的近交系小鼠，对于剖析复杂的宿主 - 病原体相互作用而言非常宝贵。对它们的研究已使宿主抗性基因座得以鉴定，包括主要组织相容性复合体（MHC）I类的几种激活自然杀伤（NK）细胞受体。在本章中，我们提供了一份实用指南，用于通过对感染细胞的特异性识别来控制针对MCMV的固有免疫的NK细胞受体的遗传定位和功能表征。
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