INSERM U908 "Growth factor signaling in breast cancer. Functional proteomics", University of Lille, IFR147, Villeneuve d'Ascq, France.
Breast Cancer Res Treat. 2010 Feb;120(1):17-24. doi: 10.1007/s10549-009-0686-5. Epub 2009 Dec 24.
Blood vessel formation (neovascularization) in tumors can occur through two mechanisms: angiogenesis and vasculogenesis. Angiogenesis results from proliferation and sprouting of existing blood vessels close to the tumor, while vasculogenesis is believed to arise from recruitment of circulating cells, largely derived from the bone marrow, and de novo clonal formation of blood vessels from these cells. Increasing evidence in animal models indicate that bone marrow-derived endothelial precursor cells (EPC) can contribute to tumor angiogenesis. This review aims to collate existing literature and provide an overview on the current knowledge of EPC involvement in breast cancer angiogenesis. We also discuss recent attempts to use EPC as biomarker and therapeutic target in clinical trials.
肿瘤中的血管形成（新生血管）可以通过两种机制发生：血管生成和血管发生。血管生成是由肿瘤附近的现有血管的增殖和发芽引起的，而血管发生据信来自循环细胞的募集，主要来源于骨髓，并从这些细胞中重新克隆形成血管。动物模型中的越来越多的证据表明，骨髓来源的内皮前体细胞（EPC）可以促进肿瘤血管生成。这篇综述旨在汇集现有文献，并提供关于 EPC 参与乳腺癌血管生成的最新知识概述。我们还讨论了最近尝试将 EPC 用作临床试验中的生物标志物和治疗靶标的尝试。
