ω-3 多不饱和脂肪酸（鱼油）补充剂可降低类风湿关节炎女性患者血清中可溶性核因子-κB 受体激活物配体/骨保护素的比值。
Fish oil supplementation decreases serum soluble receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio in female patients with rheumatoid arthritis.
机构信息
Biochemistry Laboratory, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Clin Biochem. 2010 Apr;43(6):576-80. doi: 10.1016/j.clinbiochem.2009.12.011. Epub 2009 Dec 23.
OBJECTIVE
Soluble receptor activator of nuclear factor-kappa B ligand (sRANKL) to osteoprotegerin ratio is designated as a bone metabolism equation in many rheumatologic disorders and would be modified with fish oil (FO) supplementation.
DESIGN AND METHODS
Eighty-three females with rheumatoid arthritis were divided randomly to 40 and 43 patients treated with (1 g/day) or without FO for 3 months accompanied with conventional drugs, respectively. Osteoprotegerin, sRANKL, tumor necrosis factor alpha (TNFalpha) serum levels were measured before and after treatment.
RESULTS
Serum levels of osteoprotegerin increased, although sRANKL, TNFalpha and sRANKL/osteoprotegerin ratio decreased with FO therapy. A significant positive correlation was observed between sRANKL/osteoprotegerin ratio and TNFalpha levels (r=0.327, p=0.040) in the FO-treated group.
CONCLUSIONS
FO could decrease the inflammatory response by lowering of serum TNFalpha levels and sRANKL/osteoprotegerin ratio.
目的
在许多风湿性疾病中，核因子-κB 配体可溶性受体（sRANKL）与护骨素的比值被指定为骨代谢方程，并可通过鱼油（FO）补充进行修正。
设计与方法
83 名女性类风湿关节炎患者被随机分为两组，40 名和 43 名患者分别接受（每天 1 克）或不接受 FO 治疗 3 个月，同时接受常规药物治疗。在治疗前后测量了护骨素、sRANKL、肿瘤坏死因子-α（TNFalpha）的血清水平。
结果
FO 治疗后，血清护骨素水平升高，尽管 sRANKL、TNFalpha 和 sRANKL/护骨素比值下降。在 FO 治疗组中，sRANKL/护骨素比值与 TNFalpha 水平呈显著正相关（r=0.327，p=0.040）。
结论
FO 通过降低血清 TNFalpha 水平和 sRANKL/护骨素比值来减轻炎症反应。
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