Department of Thoracic, Head and Neck Surgery, Jules Bordet Institute, Free University of Brussels, 1000 Brussels, Belgium.
Eur Arch Otorhinolaryngol. 2010 Jun;267(6):955-60. doi: 10.1007/s00405-009-1174-6. Epub 2009 Dec 25.
Surgical management of Graves' disease is still debated. We report our current experience with thyroidectomy for Graves' disease at a tertiary center. A retrospective database of 132 patients who underwent surgery for Graves' disease from January 1985 to December 2008 was collected. During that period, 16 patients underwent subtotal thyroidectomy and 116 patients underwent near total thyroidectomy. Eighty-seven patients (66%) underwent surgery for recurrent disease after medical therapy. Forty-five patients (34%) had surgery as a primary treatment, the indications were large goiter size in 22 (17%), patient preference in 19 (14%), and associated cold nodule in 3 (2%). The incidence of cancer was 4.4%. Permanent hypoparathyroidism was observed in one patient who underwent a second surgery for recurrence. Unilateral transitory vocal cord palsy was observed in nine patients (7%), bilateral transitory vocal cord palsy was observed in one patient, and no definitive vocal cord palsy was observed. Two patients (1.5%) experienced post-operative hemorrhagia requiring surgical revision. Near total thyroidectomy for Graves' disease provides an immediate and definitive treatment with a low complication rate. Near total thyroidectomy offers an appropriate treatment for coexisting malignancy. This procedure can be safely recommended as a primary treatment, in experienced hands.
格雷夫斯病的手术治疗仍存在争议。我们报告了在一家三级中心进行的格雷夫斯病甲状腺切除术的当前经验。收集了 1985 年 1 月至 2008 年 12 月期间因格雷夫斯病接受手术的 132 例患者的回顾性数据库。在此期间,16 例患者接受了次全甲状腺切除术,116 例患者接受了近全甲状腺切除术。87 例(66%)因药物治疗后疾病复发而行手术治疗。45 例(34%)为原发性手术治疗,适应证为大甲状腺肿 22 例(17%),患者偏好 19 例(14%)和伴有冷结节 3 例(2%)。癌症的发病率为 4.4%。1 例因复发而行二次手术的患者发生永久性甲状旁腺功能减退症。9 例(7%)患者出现单侧暂时性声带麻痹,1 例患者出现双侧暂时性声带麻痹,无明确的声带麻痹。2 例(1.5%)患者发生术后出血,需手术修正。近全甲状腺切除术为格雷夫斯病提供了一种即时和确定性的治疗方法,并发症发生率低。近全甲状腺切除术为并存恶性肿瘤提供了适当的治疗方法。在有经验的医生手中,该手术可以安全地推荐作为原发性治疗。