Leveziel Nicolas, Soubrane Gisèle, Souied Eric H
Service d'ophtalmologie (Pr Eric Souied), Hôpital intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France.
Med Sci (Paris). 2009 Dec;25(12):1105-7. doi: 10.1051/medsci/200925121105.
Age-related macular degeneration (AMD) is the main cause of vision loss in the elderly in developed countries. The exudative AMD is the most frequent and severe form of the disease, leading to a rapid loss of vision. The results of MARINA and ANCHOR studies, two multicentric clinical trials analyzing the efficacy of anti-VEGF in exudative AMD, have showed that this modality of treatment results in a stabilisation of the visual acuity in most cases (70%), and in visual improvement in 30 % of the cases. Up till now, the anti-VEGF approach represents a major step in the therapeutic strategy of this disease.
年龄相关性黄斑变性（AMD）是发达国家老年人视力丧失的主要原因。渗出性AMD是该疾病最常见、最严重的形式，会导致视力迅速丧失。MARINA和ANCHOR研究是两项分析抗VEGF药物治疗渗出性AMD疗效的多中心临床试验，其结果表明，这种治疗方式在大多数情况下（70%）可使视力稳定，30%的病例视力得到改善。到目前为止，抗VEGF治疗方法是该疾病治疗策略中的一个重大进展。
