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半规管体外模型:模型的设计和验证及其在耳石症研究中的应用。

In vitro model of a semicircular canal: design and validation of the model and its use for the study of canalithiasis.

机构信息

Institute of Fluid Dynamics, ETH Zurich, 8092 Zurich, Switzerland.

出版信息

J Biomech. 2010 Apr 19;43(6):1208-14. doi: 10.1016/j.jbiomech.2009.11.027. Epub 2009 Dec 24.

Abstract

We present an experimental model for a semicircular canal with canalithiasis. Canalithiasis is a pathological condition where free-floating particles disturb the flow field in the semicircular canals. It may lead to a specific form of vertigo known as BPPV or top-shelf vertigo. A careful scaling of the physical and geometrical parameters allows us to study the mechanics of this disease on an enlarged model of a single semicircular canal with laser vibrometry and video particle tracking. Early results confirm the proper operation of the model canal and support the current theories on the mechanisms of BPPV.

摘要

我们提出了一个具有耳石症的半规管实验模型。耳石症是一种病理状态,其中游离颗粒会扰乱半规管中的流场。它可能导致一种特定形式的眩晕,称为 BPPV 或顶架眩晕。通过仔细缩放物理和几何参数,我们可以使用激光测振仪和视频粒子跟踪技术在单个半规管的放大模型上研究这种疾病的力学。早期结果证实了模型管的正常运行,并支持了关于 BPPV 机制的当前理论。

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