Retinopathy in persons without diabetes: the Handan Eye Study.

PURPOSE

To describe the prevalence and associations of retinopathy in a population-based nondiabetic sample of rural Chinese.

DESIGN

Population-based cross-sectional study.

PARTICIPANTS

We included 6830 Han Chinese aged > or =30 years from 13 villages of Yongnian County, Handan City, Hebei Province, China.

METHODS

All participants underwent a standardized interview and extensive examinations including retinal photography, measurement of blood pressure (BP) and fasting plasma glucose (FPG). Diabetes mellitus was defined as either FPG > or = 7.0 mmol/l, use of diabetic medication or a physician diagnosis of diabetes. Photographic grading of retinopathy followed the modified Early Treatment Diabetic Retinopathy Study classification system. Logistic regression models were used to assess associations of retinopathy.

MAIN OUTCOME MEASURES

Any retinopathy.

RESULTS

The prevalence of retinopathy among participants without diabetes was 13.6% (95% confidence interval [CI], 12.6-14.6%). The age and gender standardized prevalence of retinopathy in the Chinese adult population (aged 30+ years) without diabetes was estimated to be 12.1% (95% CI 11.1-12.9%). Independent risk factors associated with retinopathy were age (odds ratio [OR], 1.02 ; 95% CI 1.01-1.03 per year increase), male gender (male vs. female, OR 1.27; 95% CI 1.08-1.49), higher FPG (OR 1.30; 95% CI 1.11-1.53 per mmol/l increase), higher systolic BP (OR 1.15; 95% CI 1.05-1.27 per 10 mmHg increase) and higher diastolic BP (OR 1.16; 95% CI 1.09-1.22 per 10 mmHg increase).

CONCLUSIONS

Retinopathy was common among rural Chinese adults without diabetes. Its association with FPG and BP suggests that early microvascular damage is occurring at "high normal" levels of blood glucose and BP.