Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
J Neuroimmunol. 2010 Feb 26;219(1-2):114-8. doi: 10.1016/j.jneuroim.2009.12.003. Epub 2009 Dec 24.
We are the first to study the relationship between oxidative stress (by measuring plasma F2-isoprostane, as a marker of lipid peroxidation, and glutathione peroxidase, as an antioxidant enzyme) and autoimmunity (as indicated by serum antineuronal antibodies) in a group of 44 Egyptian autistic children and 44 healthy matched-children. Our results showed that oxidative stress was found in 88.64% of autistic children. Oxidative stress, resulting from elevated plasma F2-isoprostane and/or reduced glutathione peroxidase, had significant risk for antineuronal positivity, which was found in 54.5% of autistic children, (odds ratio: 12.38 and 6.43, respectively, confidence interval: 1.37-112.10 and 1.21-34.19, respectively).
the strong association between oxidative stress and autoimmunity in autistic children may indicate the possible role of oxidative stress, through induction of autoimmunity, in some autistic patients. Therefore, studies considering the role of antioxidants and immunotherapy in amelioration of autistic manifestations are recommended.
我们是第一个在一组 44 名埃及自闭症儿童和 44 名健康匹配儿童中研究氧化应激（通过测量血浆 F2-异前列腺素，作为脂质过氧化的标志物，和谷胱甘肽过氧化物酶，作为抗氧化酶）和自身免疫（如血清神经元抗体所示）之间关系的小组。我们的结果表明，88.64%的自闭症儿童存在氧化应激。氧化应激，由血浆 F2-异前列腺素升高和/或谷胱甘肽过氧化物酶降低引起，对神经元阳性有显著风险，在 54.5%的自闭症儿童中发现，（比值比：分别为 12.38 和 6.43，置信区间：分别为 1.37-112.10 和 1.21-34.19）。
自闭症儿童中氧化应激与自身免疫之间的强烈关联可能表明氧化应激可能通过诱导自身免疫在一些自闭症患者中发挥作用。因此，建议进行考虑抗氧化剂和免疫疗法在改善自闭症表现中的作用的研究。
