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局部麻醉下使用A型肉毒杆菌神经毒素进行经皮化学性肌切开术治疗喉切除术后环咽肌吞咽困难

Percutaneous chemical myotomy using botulium neurtoxin A under local anaesthesia in the treatment of cricopharyngeal dysphagia following laryngectomy.

作者信息

Natt R S, McCormick M S, Clayton J M, Ryall C

机构信息

Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK.

出版信息

Auris Nasus Larynx. 2010 Aug;37(4):500-3. doi: 10.1016/j.anl.2009.11.008. Epub 2009 Dec 29.

Abstract

OBJECTIVE

The purpose of this study was to evaluate the outcome of the use of percutaneous injection of botulinum neurotoxin A under local anaesthesia in the management of cricophayngeus dysphagia in post-laryngectomy patients.

METHODS

Fifteen post-laryngectomy patients (6 males, 9 females, age range 48-72 years) with surgery performed not less than five years with post-operative radiotherapy were recruited. Under video-fluoroscopic control and the attachment of a metal safety pin to the neck as a topographical marker for the cricopharyngeus muscle, botulinum neurotoxin was injected after local anaesthesia infiltration. Patients were followed up for a 4 months period with repeated video-fluoroscopy and telephone self-assessment and weight change.

RESULTS

Eighty seven percent of patients noticed some improvement in their dysphagia. One patient reported an adverse reaction of pain at the site of injection.

CONCLUSION

Percutaneous local injection of botulinum neurotoxin A is a simple, safe and cost-effective means of improving cricopharyngeal dysphagia in post-laryngectomy patients when general anaesthesia is contra-indicated.

摘要

目的

本研究旨在评估在局部麻醉下经皮注射A型肉毒杆菌神经毒素治疗喉切除术后患者环咽肌吞咽困难的效果。

方法

招募15例喉切除术后患者(6例男性,9例女性,年龄48 - 72岁),手术时间不少于5年且术后接受过放疗。在视频透视控制下,于颈部附着一枚金属安全别针作为环咽肌的体表标记,局部麻醉浸润后注射肉毒杆菌神经毒素。对患者进行为期4个月的随访,期间重复进行视频透视检查、电话自我评估及体重变化监测。

结果

87%的患者吞咽困难症状有所改善。1例患者报告注射部位出现疼痛的不良反应。

结论

当全身麻醉禁忌时,经皮局部注射A型肉毒杆菌神经毒素是改善喉切除术后患者环咽肌吞咽困难的一种简单、安全且经济有效的方法。

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