磁场增强晶体质量。

Crystal quality enhancement by magnetic fields.

机构信息

Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.

出版信息

Prog Biophys Mol Biol. 2009 Nov;101(1-3):45-55. doi: 10.1016/j.pbiomolbio.2009.12.003. Epub 2009 Dec 30.

DOI:10.1016/j.pbiomolbio.2009.12.003

PMID:20036684

Abstract

From the latter half of the '90s, many studies of the effects of magnetic fields on protein crystallization have been carried out. It has been found that the crystallization of proteins under both homogeneous and inhomogeneous (gradient) magnetic fields enhances the quality of protein crystals. The quality enhancement is attributed to the magnetic orientation of protein crystals and the magnetic suppression of buoyancy convection in protein solutions. The magnetic fields also affect the kinetics of protein crystallization and hence change the habit of protein crystals. In this review, the effects of magnetic fields on protein crystallization, their mechanisms and indispensable future studies are outlined.

摘要

从 90 年代后半期开始，已经有许多关于磁场对蛋白质结晶影响的研究。已经发现，在均匀磁场和非均匀（梯度）磁场下，蛋白质的结晶都会提高蛋白质晶体的质量。这种质量的提高归因于蛋白质晶体的磁取向和蛋白质溶液中浮力对流的磁抑制。磁场还会影响蛋白质结晶的动力学，从而改变蛋白质晶体的形态。在这篇综述中，概述了磁场对蛋白质结晶的影响、它们的机制以及未来不可或缺的研究。