Department of Neurosurgery, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Neurosci Res. 2010 Apr;66(4):402-5. doi: 10.1016/j.neures.2009.12.014. Epub 2009 Dec 29.
Although the classic idea of controlling pain through focal brain cooling is intriguing, the mechanism of this effect still remains to be elucidated. A thermoelectronic cooling system was developed and chronically implanted on the ipsilateral sensorimotor cortex of rats. Significant suppression of nociceptive pain was observed in limbs contralateral to the cooling cortex in hot plate tests and thermal withdrawal tests (p<0.05), with a minimal influence on neurological functions. This study identified, for the first time, the specific site and temperatures for the suppression of nociceptive pain, thus showing the potential feasibility of thermal neuromodulation therapy for pain.
虽然通过大脑局部冷却来控制疼痛的经典理念很吸引人，但这种效果的机制仍有待阐明。我们开发了一种热电冷却系统，并将其长期植入大鼠对侧感觉运动皮层。在热板试验和热回避试验中，观察到对侧冷却皮层的肢体疼痛明显减轻（p<0.05），而对神经功能的影响最小。本研究首次确定了抑制伤害性疼痛的特定部位和温度，从而显示了热神经调节疗法治疗疼痛的潜在可行性。
