Department of Pharmaceutical Chemistry, National Medicines Institute, 30/34 Chełmska Street, 00-725 Warsaw, Poland.
J Chromatogr A. 2010 Feb 19;1217(8):1266-72. doi: 10.1016/j.chroma.2009.12.025. Epub 2009 Dec 16.
The Corona CAD (charged aerosol detection) is a new type of detector introduced for LC applications that has recently become widely applied in pharmaceutical analysis. The Corona CAD measures a physical property of analyte and responds to almost all non-volatile species, independently of their nature and spectral or physicochemical properties. The LC method with charged aerosol detection was developed for the determination of three isomers of atracurium, cisatracurium and also three isomers of mivacurium with their impurities. The limit of quantitation for laudanosine was 1 microg ml(-1). The elaborate method for the analysis of those active substances and laudanosine proved to be fast, precise, accurate and sensitive. All other impurities were identified using time-of-flight mass spectrometry with electrospray ionization.
电喷雾气溶胶检测（Corona CAD）是一种新型检测器，用于 LC 应用，最近已广泛应用于药物分析。Corona CAD 测量分析物的物理性质，对几乎所有非挥发性物质均有响应，而与物质的性质、光谱或物理化学性质无关。带有电喷雾气溶胶检测的 LC 方法已用于测定阿曲库铵、顺阿曲库铵的三种异构体以及米库氯铵的三种异构体及其杂质。劳丹素的定量限为 1 微克/毫升(-1)。该方法用于分析这些活性物质和劳丹素的方法被证明是快速、精确、准确和灵敏的。使用电喷雾电离飞行时间质谱法对所有其他杂质进行了鉴定。
