Karousou Evgenia, Ronga Mario, Vigetti Davide, Barcolli Daniele, Passi Alberto, Maffulli Nicola
Department of Experimental Biomedical and Clinical Sciences (DSBSC), University of Insubria, Varese, Italy.
Front Biosci (Elite Ed). 2010 Jan 1;2(1):1-12. doi: 10.2741/e59.
Tendon is a poorly vascularized and highly specialized connective tissue containing few scattered cells that play an important role in the musculoskeletal apparatus by resisting mechanical stress. Because of the slow rate of the metabolism of its molecular components, the tendon gradually loses its mechanical properties and may rupture upon an array of physical activities. In this report, we discuss the molecular changes involved in the extracellular matrix-tendon interactions leading to tissue degeneration and rupture.
肌腱是一种血管分布较少且高度特化的结缔组织，含有少量散在的细胞，这些细胞通过抵抗机械应力在肌肉骨骼系统中发挥重要作用。由于其分子成分的代谢速率缓慢，肌腱会逐渐丧失其机械性能，并可能在一系列体育活动中发生断裂。在本报告中，我们讨论了细胞外基质与肌腱相互作用中涉及的分子变化，这些变化会导致组织退变和断裂。
