Hayashi Keiko, Sengoku Norihiko, Kosaka Yoshimasa, Kondou Yasushi, Sugiyama Naoko, Enomoto Takumo, Kuranami Masaru, Watanabe Masahiko
Department of Surgery, Kitasato University.
Gan To Kagaku Ryoho. 2009 Nov;36(12):2480-3.
An 83-year-old postmenopausal woman was referred to our hospital in order to get the treatment for ER positive advanced breast cancer (T4aN2M0, stage III b). The patient was diagnosed as the dissected aortic aneurysm and the hypertension. It was decided that an operation and chemotherapy would be too difficult with high existing risks. As a result, she was treated with anastrozole of PST, a 3rd-generation aromatase inhibitor, which led to the marked regression of the left breast cancer within a month. The cancer wasn't visualized after eighteen months. With the ongoing breast-hormone Therapy, no remote metastasis has been found after thirty months to this day. The patient hasn't experienced any adverse effects with the above-mentioned therapy. We concluded that the hormone (anastrozole) therapy as PST is a useful treatment for elderly postmenopausal woman with ER positive advanced breast cancer.
一名83岁的绝经后女性因雌激素受体(ER)阳性晚期乳腺癌(T4aN2M0,Ⅲb期)前来我院接受治疗。该患者被诊断患有主动脉夹层动脉瘤和高血压。鉴于手术和化疗风险过高,难度较大,最终决定不进行手术和化疗。因此,患者接受了第三代芳香化酶抑制剂阿那曲唑的治疗,治疗一个月后左乳癌显著消退。18个月后癌症消失。在持续的乳腺激素治疗下,至今30个月未发现远处转移。患者在上述治疗过程中未出现任何不良反应。我们得出结论,作为PST的激素(阿那曲唑)疗法是治疗ER阳性晚期乳腺癌老年绝经后女性的有效方法。